Seven people were killed and six others were injured on Friday when a public bus collided with a microbus in Nasr City, Al-Ahram Arabic website reported.
A source at the health ministry told Al-Ahram Arabic website that nine ambulances were dispatched to the site and the injured were transferred to the Medical Insurance Hospital in Nasr City.
The source added that two of the injured were in critical condition.
The bodies of the dead were transferred to Zeinhom morgue in Cairo.
Horrifying photos of the accident have been circulating widely on social media.
Deadly traffic accidents take place on a daily basis in Egypt, largely due to poor road safety, badly maintained infrastructure, and loosely enforced traffic regulations.
In 2015, a total 14,548 road accidents were recorded by Egypt's official statistics agency.